Pathway / Coagulation & thrombus formation

ABO Histo-Blood Group

ABOgene

Blood-group determinant modulating von Willebrand factor and clotting-factor levels.

Pathway placement

Cascade stepCoagulation & thrombus formation

Confidencehigh

RationaleABO blood group; regulates vWF, fibrinogen, platelet function.

Also acts inPlatelet activation

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000175164

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated

R — rupture / Type-I

—

C — non-Type-I

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-35

Non-Type-I axis panel

Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.

2sepsis / systemic inflammationn/a

2anemia / acute blood lossn/a

2hypovolemia / dehydrationn/a

2tachyarrhythmian/a

2hypoxemia / respiratory failuren/a

2hypertensive emergencyn/a

2high-demand / peri-operative stressn/a

3sudden cardiac deathn/a

4aPCI-related periproceduraln/a

4bstent thrombosismag 2

4cin-stent restenosismag 1

5CABG-relatedn/a

Coverage: 2/12 axes with evidence

Tier: deep-scored (abstract-extracted) · 3 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

GWAS associations

Traits: myocardial infarction

Literature evidence(0)

No direct literature mentions harvested; included via genetic/target evidence.