Data table
All 1,948 molecules. Click a column header to sort; click a row for its evidence page. ◆ = druggable, ✦ = genetic evidence.
1,948 rows
| Molecule | Gene | Type | Step | Refs ▼ | Trials | Conf. | Flags |
|---|---|---|---|---|---|---|---|
| LDL cholesterol | — | lipoprotein | Lipid entry/oxidation | 60 | 6 | high | |
| Oxidized LDL | — | lipoprotein | Lipid entry/oxidation | 60 | 2 | high | |
| HDL | — | lipoprotein | Lipid entry/oxidation | 60 | — | medium | |
| C-reactive protein | CRP | protein | Vascular inflammation | 60 | 8 | high | ◆✦ |
| Interleukin-6 | IL6 | protein | Vascular inflammation | 60 | 1 | high | ◆✦ |
| TNF-α | TNF | protein | Vascular inflammation | 60 | 1 | high | ◆✦ |
| von Willebrand factor | VWF | protein | Endothelial activation/erosion | 60 | — | high | ◆ |
| P-selectin | SELP | protein | Platelet activation | 60 | — | high | ◆✦ |
| D-dimer | — | protein | Coagulation / thrombus | 60 | 1 | high | |
| Fibrinogen | FGA | protein | Coagulation / thrombus | 60 | — | high | ◆ |
| Plasminogen activator inhibitor-1 | SERPINE1 | protein | Coagulation / thrombus | 60 | — | medium | ◆✦ |
| B-type natriuretic peptide | NPPB | protein | Systemic / off-pathway | 60 | 1 | high | ◆✦ |
| Soluble CD40 ligand | CD40LG | protein | Platelet activation | 59 | — | high | ◆✦ |
| Interleukin-1β | IL1B | protein | Vascular inflammation | 57 | — | high | ◆ |
| Prothrombin fragment 1+2 | F2 | protein | Coagulation / thrombus | 53 | — | high | ◆✦ |
| CK-MB | CKM | protein | Myocardial injury | 50 | 1 | high | ◆ |
| Apolipoprotein B | APOB | protein | Lipid entry/oxidation | 49 | 3 | high | ◆✦ |
| Thrombin-antithrombin complex | — | protein | Coagulation / thrombus | 48 | — | high | |
| Troponin T | TNNT2 | protein | Myocardial injury | 47 | 6 | high | ◆✦ |
| Lipoprotein(a) | LPA | lipoprotein | Lipid entry/oxidation | 46 | 19 | high | ◆✦ |
| Cardiac troponin I | TNNI3 | protein | Myocardial injury | 46 | 7 | high | ◆✦ |
| sVCAM-1 | VCAM1 | protein | Endothelial activation/erosion | 44 | — | high | ◆ |
| Intercellular Adhesion Molecule 1 | ICAM1 | protein | Endothelial activation/erosion | 43 | — | high | ◆ |
| Tissue Factor | F3 | protein | Coagulation / thrombus | 41 | 1 | high | ◆ |
| Myeloperoxidase | MPO | protein | Vascular inflammation | 40 | 1 | high | ◆✦ |
| Matrix metalloproteinase-9 | MMP9 | protein | Cap degradation / rupture | 39 | — | high | ◆✦ |
| Growth differentiation factor 15 | GDF15 | protein | Systemic / off-pathway | 39 | — | medium | ◆✦ |
| Tissue plasminogen activator | PLAT | protein | Coagulation / thrombus | 38 | — | high | ◆✦ |
| Fibrinopeptide A | — | peptide | Coagulation / thrombus | 37 | — | high | |
| Platelet Factor 4 | PF4 | protein | Platelet activation | 33 | — | high | ◆ |
| Apolipoprotein A-I | APOA1 | protein | Lipid entry/oxidation | 30 | 1 | high | ◆ |
| E-selectin | SELE | protein | Endothelial activation/erosion | 30 | — | high | ◆ |
| Interleukin-10 | IL10 | protein | Vascular inflammation | 28 | — | medium | ◆ |
| Apolipoprotein E | APOE | protein | Lipid entry/oxidation | 26 | — | medium | ◆✦ |
| PCSK9 | PCSK9 | protein | Lipid entry/oxidation | 25 | 20 | high | ◆✦ |
| Beta-Thromboglobulin | PPBP | protein | Platelet activation | 25 | — | high | ◆ |
| Integrin alpha IIb | ITGA2B | protein | Platelet activation | 25 | — | high | ◆✦ |
| Thrombin | — | protein | Coagulation / thrombus | 25 | 1 | high | |
| Fibrinogen Beta Chain | FGB | protein | Coagulation / thrombus | 25 | — | high | ◆ |
| Lipoprotein-associated Phospholipase A2 | PLA2G7 | protein | Vascular inflammation | 24 | 4 | high | ◆✦ |
| Monocyte Chemoattractant Protein-1 | CCL2 | protein | Vascular inflammation | 24 | — | high | ◆ |
| Lysophosphatidylcholine | — | lipid | Lipid entry/oxidation | 23 | — | medium | |
| thrombomodulin | THBD | protein | Endothelial activation/erosion | 23 | — | high | ◆ |
| Lectin-like Oxidized LDL Receptor 1 | — | protein | Lipid entry/oxidation | 22 | — | high | |
| Nitric oxide | — | metabolite | Endothelial activation/erosion | 22 | 3 | high | |
| Endothelial nitric oxide synthase | NOS3 | protein | Endothelial activation/erosion | 22 | — | high | ◆✦ |
| Very-Low-Density Lipoprotein | — | lipoprotein | Lipid entry/oxidation | 21 | — | high | |
| Interleukin-18 | IL18 | protein | Vascular inflammation | 21 | — | high | ◆ |
| Interleukin-8 | CXCL8 | protein | Vascular inflammation | 21 | — | high | ◆✦ |
| ST2 | IL1RL1 | protein | Systemic / off-pathway | 21 | — | high | ◆ |
| Vascular endothelial growth factor | VEGFA | protein | Endothelial activation/erosion | 20 | 1 | medium | ◆ |
| Glycoprotein VI | GP6 | protein | Platelet activation | 20 | — | high | ◆✦ |
| CD31 | — | protein | Endothelial activation/erosion | 19 | — | medium | |
| Fibrin | — | protein | Coagulation / thrombus | 19 | — | high | |
| antithrombin III | SERPINC1 | protein | Coagulation / thrombus | 19 | — | medium | ◆✦ |
| Phosphatidylcholine | — | lipid | Lipid entry/oxidation | 18 | — | high | |
| Adiponectin | ADIPOQ | protein | Vascular inflammation | 18 | — | high | ◆ |
| Glycoprotein Ib | GP1BA | protein | Platelet activation | 18 | — | high | ◆ |
| H-FABP | FABP3 | protein | Myocardial injury | 18 | 1 | high | ◆ |
| Sphingomyelin | — | lipid | Lipid entry/oxidation | 17 | — | medium | |
| LDL Receptor | LDLR | gene | Lipid entry/oxidation | 17 | 3 | high | ◆✦ |
| homocysteine | — | metabolite | Endothelial activation/erosion | 17 | — | medium | |
| Cystatin C | CST3 | protein | Systemic / off-pathway | 17 | — | high | ◆✦ |
| Ceramide | — | lipid | Lipid entry/oxidation | 16 | — | high | |
| HDL cholesterol | — | lipoprotein | Lipid entry/oxidation | 16 | 1 | high | |
| Plasminogen | PLG | protein | Coagulation / thrombus | 16 | 1 | high | ◆✦ |
| Triglycerides | — | lipid | Lipid entry/oxidation | 15 | 2 | high | |
| NLRP3 inflammasome | NLRP3 | protein | Vascular inflammation | 15 | 1 | medium | |
| Thromboxane B2 | — | metabolite | Thromboxane / COX-1 | 15 | — | high | |
| Interferon-Gamma | IFNG | protein | Vascular inflammation | 14 | — | high | ◆ |
| PECAM-1 | PECAM1 | protein | Endothelial activation/erosion | 14 | — | medium | ◆✦ |
| Phosphatidylserine | — | lipid | Platelet activation | 14 | — | medium | |
| Factor VII | F7 | protein | Coagulation / thrombus | 14 | — | high | ◆ |
| Copeptin | AVP | peptide | Myocardial injury | 14 | 5 | high | ◆✦ |
| Myoglobin | MB | protein | Myocardial injury | 14 | — | high | ◆✦ |
| Trimethylamine N-oxide | — | metabolite | Lipid entry/oxidation | 13 | — | high | |
| Matrix Metalloproteinase-2 | MMP2 | protein | Cap degradation / rupture | 13 | — | high | ◆ |
| CD36 molecule | CD36 | protein | Platelet activation | 13 | — | high | ◆ |
| CD39 | ENTPD1 | protein | Platelet activation | 13 | — | high | ◆ |
| arachidonic acid | — | metabolite | Thromboxane / COX-1 | 13 | — | high | |
| CD34 | — | protein | Endothelial activation/erosion | 12 | — | medium | |
| Fibronectin | FN1 | protein | Platelet activation | 12 | — | high | ◆✦ |
| Factor XI | F11 | protein | Coagulation / thrombus | 12 | — | high | ◆ |
| Transforming Growth Factor-Beta | TGFB1 | protein | Myocardial injury | 12 | — | medium | ◆✦ |
| Lactate dehydrogenase | LDHA | protein | Myocardial injury | 12 | — | medium | ◆ |
| Serum Amyloid A | SAA1 | protein | Vascular inflammation | 11 | — | high | ◆ |
| Pregnancy-associated Plasma Protein A | PAPPA | protein | Cap degradation / rupture | 11 | — | high | ◆✦ |
| Soluble lectin-like oxidized LDL receptor 1 | OLR1 | protein | Endothelial activation/erosion | 11 | 1 | high | ◆✦ |
| Vascular Endothelial Cadherin | CDH5 | protein | Endothelial activation/erosion | 11 | — | high | ◆ |
| phosphatidylethanolamine | — | lipid | Platelet activation | 11 | — | high | |
| Adenosine diphosphate | — | metabolite | Platelet activation | 11 | 1 | high | |
| Integrin αIIbβ3 | — | protein | Platelet activation | 11 | — | high | |
| Tissue factor pathway inhibitor | TFPI | protein | Coagulation / thrombus | 11 | — | high | ◆ |
| Coagulation factor VIII | F8 | protein | Coagulation / thrombus | 11 | — | medium | ◆ |
| Factor V | F5 | protein | Coagulation / thrombus | 11 | — | high | ◆ |
| Ceramides | — | lipid | Lipid entry/oxidation | 10 | — | high | |
| Pentraxin-3 | PTX3 | protein | Vascular inflammation | 10 | — | high | ◆✦ |
| CD40 | CD40 | gene | Vascular inflammation | 10 | — | high | ◆ |
| S100A9 | S100A9 | protein | Vascular inflammation | 10 | — | high | ◆ |
| S100A8 | S100A8 | protein | Vascular inflammation | 10 | — | high | ◆ |