Type-I MI diagnostic-utility explorer

Rank every biomarker for its usefulness in diagnosing Type-I (atherothrombotic) MI. Each marker carries six evidence-anchored sub-scores; you decide how much each one matters using the sliders. The composite and the ranking recompute instantly. Start from a preset (rule-in, deployable-today, novel discovery) or set your own weights. Scores with no evidence show — and are never invented.

Three axes are directly diagnostic — Diagnostic performance (sensitivity/specificity/AUC), Release kinetics (how early it rises), and Incremental value vs troponin — extracted from accuracy studies. Only ~14 markers have any of this data (procalcitonin, troponin T, Cardiac troponin T/I, myoglobin, CK-MB, cMyBP-C for kinetics; MR-proADM, ApoJ-Glyc, IMA, cystatin C for accuracy; GDF-15, ST2, BNP, myoglobin, troponin T, MR-proADM, CK-MB, Creatine kinase-MB, cMyBP-C for incremental value); for everything else these show —. That sparsity is itself the finding: very few candidates have been studied as an MI index test the way troponin has.

ⓘ Methodology — how the criteria and the ranking are built

This explorer scores each biomarker against nine criteria, each normalized to 0–100 (higher is better for a Type-I diagnostic), and combines them into a single composite using weights you set. The criteria fall into three groups. Discrimination criteria — plaque-rupture signal (R), specificity vs demand (the confounder score C, inverted), and direct T1 > T2 evidence (D) — come from the atlas's Type-I-vs-Type-II scoring and capture whether a marker reflects atherothrombosis rather than the supply–demand mismatch of a Type-II MI. Direct diagnostic criteria — diagnostic performance (sensitivity/specificity/AUC), release kinetics (how early it rises), and incremental value vs troponin — are extracted from index-test / accuracy studies in the literature; only ~14 markers have any of this data, and the rest correctly show — rather than a fabricated value. Practical criteria — assay feasibility, evidence strength, and novelty — capture deployability and how under-explored a marker is (incumbents already in clinical use are capped low so they never register as novel).

Composite. The score is a weighted average of the available sub-scores. When “penalize missing data” is on, the average divides by the total weight you assigned, so a marker with unmeasured criteria is pulled down — this rewards markers that have actually been studied across the board. Turn it off to divide only by the weight of the criteria a marker does have, scoring each marker on its own evidence. Presets (rule-in, deployable-today, best diagnostic test, novel discovery) are just saved weight profiles; every weight remains adjustable.

Hover (or tab to) any criterion label or table column header for its definition. Scores are evidence-anchored inferences for hypothesis prioritization, not a validated clinical instrument — see the Methods page for the full harvest and scoring provenance.

Weight the criteria

Drag to set how much each dimension matters. Ranking updates live.

Plaque-rupture signal90

Specificity vs demand100

Direct T1 > T2 evidence90

Diagnostic performance0

Release kinetics0

Incremental vs troponin0

Assay feasibility40

Evidence strength50

Novelty10

Penalize missing data (markers with gaps rank lower)

1060 ranked

Top 15 by your weighting

1Cardiac troponin I

2Cardiac troponins

3CK-MB

4Creatine kinase-MB

5Creatine Kinase

6Copeptin

7Cardiac Myosin-Binding Protein C

8Troponin T

9Neutrophil gelatinase-associated lipocalin (NGAL)

10Lactate

11Methylglyoxal

12Cardiac troponin

13SRC tyrosine kinase

14PCSK9

15Transforming Growth Factor-Beta

#	Marker	Score	Rupt	Dem.spec	T1>T2	Perf	Kin	Incr	Feas	Evid	Novel	Class
1	Cardiac troponin ITNNI3	75	100	42	83	—	—	—	96	78	12	Shared / rises in both
2	Cardiac troponins	73	100	33	83	—	—	—	68	100	12	Shared / rises in both
3	CK-MBCKM	72	67	50	83	—	85	40	96	100	12	Shared / rises in both
4	Creatine kinase-MB	70	100	33	67	—	—	40	96	86	12	Shared / rises in both
5	Creatine Kinase	67	67	29	83	—	—	—	96	100	12	Shared / rises in both
6	CopeptinAVP	62	67	42	83	—	—	—	84	42	50	Shared / rises in both
7	Cardiac Myosin-Binding Protein CMYBPC3	58	67	33	67	—	100	75	68	67	82	Shared / rises in both
8	Troponin TTNNT2	56	100	40	—	—	60	20	96	85	12	Shared / rises in both
9	Neutrophil gelatinase-associated lipocalin (NGAL)LCN2	54	100	44	—	—	—	—	68	73	60	Shared / rises in both
10	Lactate	53	67	52	—	—	—	—	96	86	82	Indeterminate
11	Methylglyoxal	53	100	44	—	—	—	—	42	84	90	Shared / rises in both
12	Cardiac troponin	53	100	39	—	—	—	—	96	65	12	Shared / rises in both
13	SRC tyrosine kinaseSRC	52	100	44	—	—	—	—	72	54	68	Shared / rises in both
14	PCSK9PCSK9	51	67	50	—	—	—	—	72	95	56	Shared / rises in both
15	Transforming Growth Factor-BetaTGFB1	50	67	58	—	—	—	—	72	75	66	Indeterminate
16	Methionine	50	67	75	—	—	—	—	42	60	90	Type-I-specific
17	C-X-C Chemokine Receptor Type 4CXCR4	50	67	60	—	—	—	—	52	86	70	Indeterminate
18	ADAMTS13ADAMTS13	50	67	58	—	—	—	—	72	69	78	Indeterminate
19	Growth differentiation factor 15GDF15	49	100	22	—	—	—	40	84	73	51	Shared / rises in both
20	ChymaseCMA1	49	100	33	—	—	—	—	72	53	76	Shared / rises in both
21	Integrin alphaIIbbeta3	49	86	57	—	—	—	—	68	32	84	Low-confidence (proxy)
22	Albumin	49	67	58	—	—	—	—	84	52	71	Indeterminate
23	Anti-β2-glycoprotein I antibodies	49	79	63	—	—	—	—	68	29	92	Low-confidence (proxy)
24	FOXP3FOXP3	49	67	53	—	—	—	—	52	86	76	Indeterminate
25	LDL cholesterol	48	67	47	—	—	—	—	84	82	23	Shared / rises in both
26	B-type natriuretic peptideNPPB	48	67	50	—	—	—	40	96	67	12	Shared / rises in both
27	Integrin αIIbβ3	48	86	57	—	—	—	—	68	32	60	Low-confidence (proxy)
28	Matrix Metalloproteinase-2MMP2	48	67	50	—	—	—	—	72	75	57	Shared / rises in both
29	Ischemia-modified albuminALB	48	67	50	—	63	—	—	84	65	53	Shared / rises in both
30	Glycoprotein VIGP6	48	90	49	—	—	—	—	72	33	53	Low-confidence (proxy)
31	Interleukin-2IL2	47	67	56	—	—	—	—	68	58	68	Indeterminate
32	Plasminogen activator inhibitor-1SERPINE1	47	67	58	—	—	—	—	72	58	26	Indeterminate
33	von Willebrand factorVWF	47	67	39	—	—	—	—	72	95	22	Shared / rises in both
34	ERK1/2	47	67	44	—	—	—	—	68	75	80	Shared / rises in both
35	Immunoglobulin G	47	67	42	—	—	—	—	68	86	51	Shared / rises in both
36	ST2IL1RL1	46	67	44	—	—	—	40	84	66	56	Shared / rises in both
37	Angiotensin-Converting Enzyme 2ACE2	46	67	56	—	—	—	—	68	52	77	Indeterminate
38	Cytochrome b-245 Alpha SubunitCYBA	46	67	67	—	—	—	—	52	39	82	Indeterminate
39	Heparin Cofactor IISERPIND1	46	81	52	—	—	—	—	68	30	88	Low-confidence (proxy)
40	Peroxisome proliferator-activated receptor	46	67	39	—	—	—	—	68	80	88	Shared / rises in both

How the composite works: each sub-score is 0–100 (higher = better for a Type-I diagnostic). The composite is a weighted average of the sub-scores using your slider weights. “Penalize missing data” divides by the total weight rather than only the covered weight, so markers with gaps rank lower — turn it off to score markers on the evidence they do have. This is a hypothesis-prioritization tool, not a validated clinical instrument.