ACAD10
ACAD10proteinACAD10 controls platelet mitochondrial homeostasis and activation state, modulating the thrombotic response to vascular injury.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleRegulates platelet mitophagy and activation during thrombosis.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000111271
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Human genetic evidence
1
GWAS associations
Traits: myocardial infarction
Literature evidence(1)
- The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis.Circulation · 2026 · PMID 41645907 · doi