ADAMTS7 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 7)

ADAMTS7gene

Matrix metalloproteinase promoting fibrous-cap degradation, arterial calcification, and endothelial dysfunction driving atherosclerotic MI.

Pathway placement

Cascade stepFibrous-cap degradation & rupture

Confidencehigh

RationaleECM-degrading protease; arterial calcification and cap remodeling; atherosclerosis/MI pathogenesis.

Also acts inLipid entry/oxidation, Endothelial activation/erosion

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000136378

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable