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Protein kinase B
Pathway / Platelet adhesion & activation

Protein kinase B

AKT1gene

AKT phosphorylation amplifies platelet activation via PI3K, while also promoting endothelial repair and cardiomyocyte survival through eNOS and mitochondrial protection.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePlatelet activation signaling; eNOS activation for endothelial function; cardioprotective survival kinase.
Also acts inEndothelial activation/erosion, Myocardial injury, Systemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates15
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000142208

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
58
A — assay feasibility
52
E — evidence strength
42
T1DI (composite)
12
Specificity differential (R−C)+8.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmiamag 1
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressmag 2
3sudden cardiac deathn/a
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedn/a
Coverage: 4/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 19 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(8)