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Protein kinase B
Pathway / Platelet adhesion & activation

Protein kinase B

AKT1gene

AKT phosphorylation amplifies platelet activation via PI3K, while also promoting endothelial repair and cardiomyocyte survival through eNOS and mitochondrial protection.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePlatelet activation signaling; eNOS activation for endothelial function; cardioprotective survival kinase.
Also acts inEndothelial activation/erosion, Myocardial injury, Systemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates15
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000142208

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
56
A — assay feasibility
52
E — evidence strength
42
T1DI (composite)
12
Specificity differential (R−C)+11.1
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuren/a
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 3/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 17 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(8)