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Aldehyde Dehydrogenase 2
Pathway / Platelet adhesion & activation

Aldehyde Dehydrogenase 2

ALDH2gene

ALDH2 controls acetaldehyde and reactive-aldehyde detoxification, regulating platelet activation state and thrombotic predisposition in acute coronary events.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleRegulates platelet activation and arterial thrombosis directly.
Also acts inCoagulation / thrombus
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000111275

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
32
C — confounder / Type-II
73
A — assay feasibility
52
E — evidence strength
27
T1DI (composite)
4
Specificity differential (R−C)-41.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

4
GWAS associations
Traits: myocardial infarction

Literature evidence(3)

Omics datasets(1)