ATP1A1

ATP1A1gene

ATP1A1 encodes Na/K-ATPase α1, which maintains platelet ion homeostasis and contractility, supporting but not directly driving thrombotic activation.

Pathway placement

Cascade stepPlatelet adhesion & activation

Confidencelow

RationaleNa/K-ATPase catalytic subunit; broad cellular role; peripheral.

Druggability

DruggableYes

Known drugs / candidates6

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000163399

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable