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Chymase
Pathway / Fibrous-cap degradation & rupture

Chymase

CMA1protein

Chymase from activated mast cells degrades fibrous-cap matrix proteins, contributing to cap thinning and rupture in destabilizing plaques.

Pathway placement
Cascade stepFibrous-cap degradation & rupture
Confidencemedium
RationaleMast-cell protease; extracellular-matrix degradation and fibrous-cap remodeling.
Also acts inVascular inflammation, Endothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000092009

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
100
C — non-Type-I
57
A — assay feasibility
72
E — evidence strength
53
T1DI (composite)
27
Specificity differential (R−C)+42.9
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossmag 2
2hypovolemia / dehydrationmag 3
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuremag 1
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathn/a
4aPCI-related periproceduraln/a
4bstent thrombosismag 1
4cin-stent restenosismag 2
5CABG-relatedmag 1
Coverage: 7/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.083
Open Targets association (acute_MI)

Literature evidence(2)