Collagen type V alpha-2 chain

COL5A2gene

COL5A2 is a structural collagen involved in post-MI fibrotic cardiac remodeling.

Pathway placement

Cascade stepFibrous-cap degradation & rupture

Confidencemedium

RationaleExtracellular matrix protein; post-MI fibrosis and structural remodeling.

Also acts inMyocardial injury

Druggability

DruggableYes

Known drugs / candidates2

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000204262

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable