Collagen VI alpha-3

COL6A3gene

COL6A3 maintains extracellular matrix integrity in the arterial wall and atherosclerotic plaque, supporting fibrous-cap resistance to degradation.

Pathway placement

Cascade stepFibrous-cap degradation & rupture

Confidencemedium

RationaleConnective-tissue structural gene; aortic matrix integrity links to fibrous-cap stability.

Also acts inLipid entry/oxidation

Druggability

DruggableYes

Known drugs / candidates2

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000163359

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

GWAS associations

Traits: myocardial infarction