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C-X-C Chemokine Receptor Type 4
Pathway / Platelet adhesion & activation

C-X-C Chemokine Receptor Type 4

CXCR4gene

CXCR4 mediates CXCL12-driven platelet activation and pro-thrombotic signaling, contributing to atherothrombotic cascade.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationalePlatelet CXCL12 receptor; pro-thrombotic signaling and platelet activation.
Also acts inVascular inflammation, Endothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates8
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000121966

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
67
C — confounder / Type-II
40
A — assay feasibility
52
E — evidence strength
86
T1DI (composite)
28
Specificity differential (R−C)+26.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 0
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 1
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 12 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.075
Open Targets association (STEMI)

Literature evidence(8)