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C-X-C Chemokine Receptor Type 4
Pathway / Platelet adhesion & activation

C-X-C Chemokine Receptor Type 4

CXCR4gene

CXCR4 mediates CXCL12-driven platelet activation and pro-thrombotic signaling, contributing to atherothrombotic cascade.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationalePlatelet CXCL12 receptor; pro-thrombotic signaling and platelet activation.
Also acts inVascular inflammation, Endothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates8
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000121966

Type I vs non-Type I discrimination

ScoresIndeterminate
R — rupture / Type-I
67
C — non-Type-I
46
A — assay feasibility
52
E — evidence strength
86
T1DI (composite)
27
Specificity differential (R−C)+20.9
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 0
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 1
2high-demand / peri-operative stressmag 1
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 1
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 8/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 19 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.075
Open Targets association (STEMI)

Literature evidence(8)