Extracellular Matrix Protein 1
ECM1proteinECM1 affects extracellular matrix integrity and vascular stability in SCAD.
Pathway placement
Cascade stepFibrous-cap degradation & rupture
Confidencemedium
RationaleECM component; likely causal in SCAD vascular pathogenesis.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000143369
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection.Circulation. Genomic and precision medicine · 2026 · PMID 41608794 · doi
Omics datasets(1)
- PXD027626PRIDEExtracellular Matrix Protein 1 as a critical mediator of inflammation-to-fibrosis crosstalk in wound healing after myocardial infarction