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Protease-activated receptor 1
Pathway / Coagulation & thrombus formation

Protease-activated receptor 1

F2Rprotein

G-protein-coupled receptor activated by thrombin; drives both platelet activation and endothelial pro-inflammatory signaling during thrombosis.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleThrombin receptor on platelets and endothelium; direct mediator of coagulation-triggered platelet activation.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates4
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000181104

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
80
C — confounder / Type-II
71
A — assay feasibility
72
E — evidence strength
31
T1DI (composite)
12
Specificity differential (R−C)+9.1
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.546
Open Targets association (myocardial_infarction)

Literature evidence(6)