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Tissue Factor
Pathway / Coagulation & thrombus formation

Tissue Factor

F3protein

Tissue Factor is exposed on thrombogenic lipid-core material after plaque rupture, triggering Factor VIIa and thrombin generation.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleTissue Factor initiates the extrinsic coagulation cascade; anchoring molecule of coagulation.
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000117525

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
53
A — assay feasibility
72
E — evidence strength
86
T1DI (composite)
19
Specificity differential (R−C)-38.3
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 10 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(41)

Showing 40 of 41 linked references.

Clinical trials(1)