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Fibrinogen
Pathway / Coagulation & thrombus formation

Fibrinogen

FGAprotein

Fibrinogen is the substrate for thrombin-driven fibrin polymerization forming the occlusive coronary thrombus.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleAnchor molecule; fibrin polymerization and thrombus strength in occlusive event.
Druggability
DruggableYes
Known drugs / candidates5
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000171560

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
56
A — assay feasibility
96
E — evidence strength
40
T1DI (composite)
11
Specificity differential (R−C)-40.6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 1
4bstent thrombosismag 2
4cin-stent restenosisn/a
5CABG-relatedn/a
Coverage: 3/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 2 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Clauss clotting-time assay
Reagent / substrate
Excess thrombin reagent; clot-time inversely proportional to fibrinogen
Platform
Coagulation analyzer
Turnaround · availability
STAT · Universal

Literature evidence(60)

Showing 40 of 60 linked references.