Fibrinogen
FGAproteinFibrinogen is the substrate for thrombin-driven fibrin polymerization forming the occlusive coronary thrombus.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleAnchor molecule; fibrin polymerization and thrombus strength in occlusive event.
Druggability
DruggableYes
Known drugs / candidates5
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000171560
Assay & specimen
Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Clauss clotting-time assay
Reagent / substrate
Excess thrombin reagent; clot-time inversely proportional to fibrinogen
Platform
Coagulation analyzer
Turnaround · availability
STAT · Universal
Literature evidence(60)
- Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2009 · PMID 19171469 · doi
- Circulating inflammatory and hemostatic biomarkers are associated with risk of myocardial infarction and coronary death, but not angina pectoris, in older men.Journal of thrombosis and haemostasis : JTH · 2009 · PMID 19682232 · doi
- Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test.Thrombosis and haemostasis · 2008 · PMID 18278189 · doi
- Do we need to consider inflammatory markers when we treat atherosclerotic disease?Atherosclerosis · 2008 · PMID 18420211 · doi
- Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study.European heart journal · 2008 · PMID 18621771 · doi
- Characterization of the pro-thrombotic state in CAPD patients.Renal failure · 2008 · PMID 18661409 · doi
- The application of proteomics technology to thrombosis research: the identification of potential therapeutic targets in cardiovascular disease.Diabetes & vascular disease research · 2008 · PMID 18777494 · doi
- Atherothrombosis: environmental links.Journal of basic and clinical physiology and pharmacology · 2008 · PMID 19024794 · doi
- Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina?American heart journal · 2007 · PMID 18035075 · doi
- Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis.The American journal of clinical nutrition · 2006 · PMID 16522902 · doi
- Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction.Thrombosis and haemostasis · 2006 · PMID 16525568 · doi
- Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation.Clinical cardiology · 2006 · PMID 16649726 · doi
- Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis.Arteriosclerosis, thrombosis, and vascular biology · 2006 · PMID 16917107 · doi
- Measures of thrombosis and fibrinolysis.Clinics in laboratory medicine · 2006 · PMID 16938589 · doi
- Tissue plasminogen activator antigen is strongly associated with myocardial infarction in young women.Journal of thrombosis and haemostasis : JTH · 2005 · PMID 15670033 · doi
- The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury.Nature medicine · 2005 · PMID 15723073 · doi
- Tissue factor pathway inhibitor, natural coagulation inhibitors and hemostatic activation markers in patients with acute coronary syndromes.Saudi medical journal · 2005 · PMID 15983678
- Increased levels of soluble tissue factor during long-term treatment with warfarin in patients after an acute myocardial infarction.Journal of thrombosis and haemostasis : JTH · 2004 · PMID 15099277 · doi
- Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes.BMC medical genetics · 2004 · PMID 15171792 · doi
- C-reactive protein, prothrombotic imbalance and endothelial dysfunction in acute coronary syndromes without ST elevation.Romanian journal of internal medicine = Revue roumaine de medecine interne · 2004 · PMID 15529598
- A randomized comparison of the effects of aspirin and clopidogrel on thrombotic risk factors and C-reactive protein following myocardial infarction: the CADET trial.Journal of thrombosis and haemostasis : JTH · 2004 · PMID 15550024 · doi
- Processing of serum proteins underlies the mass spectral fingerprinting of myocardial infarction.Journal of proteome research · 2003 · PMID 12938926 · doi
- [Fibrinogen and atherothrombosis: vulnerable plaque or vulnerable patient?].Herz · 2003 · PMID 14569394 · doi
- Fibrinogen--marker or mediator of vascular disease?Vascular medicine (London, England) · 2003 · PMID 14989564 · doi
- Coagulation indicators in chronic stable effort angina and unstable angina: relationship with acute phase reactants and clinical outcome.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2002 · PMID 11943939 · doi
- Retained fibrinolytic response and no coagulation activation after acute physical exercise in middle-aged women with previous myocardial infarction.Thrombosis research · 2002 · PMID 12091046 · doi
- Inflammation, fibrinogen and thrombin generation in patients with previous myocardial infarction.Haematologica · 2002 · PMID 12091125
- Absence of paradoxical thrombin activation by fibrin-specific thrombolytics in acute myocardial infarction: comparison of single-bolus tenecteplase and front-loaded alteplase.Thrombosis research · 2002 · PMID 12182909 · doi
- Induction of platelet thrombi by bacteria and antibodies.Blood · 2002 · PMID 12393652 · doi
- Observation on tissue factor pathway and some other coagulation parameters during the onset of acute cerebrocardiac thrombotic diseases.Thrombosis research · 2002 · PMID 12479882 · doi
- Procoagulant effects of thrombolytic therapy in acute myocardial infarction.Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih · 2002 · PMID 12894883
- Factor V Leiden and its relation to left ventricular thrombus in acute myocardial infarction.Acta cardiologica · 2001 · PMID 11315119 · doi
- Effect of the Pl(A2) alloantigen on the function of beta(3)-integrins in platelets.Blood · 2001 · PMID 11342435 · doi
- Laboratory markers of hypercoagulability.Italian heart journal : official journal of the Italian Federation of Cardiology · 2001 · PMID 11501955
- Fibrin specificity and procoagulant effect related to the kallikrein-contact phase system and to plasmin generation with double-bolus reteplase and front-loaded alteplase thrombolysis in acute myocardial infarction.The American journal of cardiology · 2000 · PMID 10922430 · doi
- D-Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain.American heart journal · 2000 · PMID 10966534 · doi
- A pilot study of streptokinase-induced endothelial injury and platelet activation following acute myocardial infarction.Journal of internal medicine · 2000 · PMID 11086642 · doi
- [Blood coagulation and fibrinolysis in arteriosclerosis].Zeitschrift fur Kardiologie · 1999 · PMID 10413853 · doi
- Elevated high molecular weight fibrinogen in plasma is predictive of coronary ischemic events after acute myocardial infarction.Thrombosis and haemostasis · 1999 · PMID 10595627
- Activation markers of coagulation and fibrinolysis: alterations and predictive value in acute coronary syndromes.Thrombosis and haemostasis · 1999 · PMID 10695492
Showing 40 of 60 linked references.