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Fibrinogen
Pathway / Coagulation & thrombus formation

Fibrinogen

FGAprotein

Fibrinogen is the substrate for thrombin-driven fibrin polymerization forming the occlusive coronary thrombus.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleAnchor molecule; fibrin polymerization and thrombus strength in occlusive event.
Druggability
DruggableYes
Known drugs / candidates5
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000171560

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Clauss clotting-time assay
Reagent / substrate
Excess thrombin reagent; clot-time inversely proportional to fibrinogen
Platform
Coagulation analyzer
Turnaround · availability
STAT · Universal

Literature evidence(60)

Showing 40 of 60 linked references.