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Fibrinogen Beta Chain
Pathway / Coagulation & thrombus formation

Fibrinogen Beta Chain

FGBprotein

Fibrinogen polymerizes into fibrin scaffolding the occlusive coronary thrombus and amplifies platelet aggregation.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleFibrinogen anchor; structural component of fibrin clot; platelet aggregation ligand; thrombus formation.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates5
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000171564

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
96
E — evidence strength
60
T1DI (composite)
14
Specificity differential (R−C)-51.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuren/a
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 1/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 20 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Clauss clotting-time assay
Reagent / substrate
Excess thrombin reagent; clot-time inversely proportional to fibrinogen
Platform
Coagulation analyzer
Turnaround · availability
STAT · Universal

Literature evidence(25)