FYVE, RhoGEF and PH Domain Containing 6

FGD6protein

FGD6, elevated during acute MI, may regulate small-GTPase signaling in platelet or endothelial dysfunction.

Pathway placement

Cascade stepPlatelet adhesion & activation

Confidencelow

RationaleGuanine-nucleotide exchange factor; elevated in incident AMI; possible role in platelet regulation.

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000180263

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)

GWAS associations

Traits: myocardial infarction