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Fibrinogen-Like Protein 1
Pathway / Fibrous-cap degradation & rupture

Fibrinogen-Like Protein 1

FGL1protein

FGL1 is released following plaque rupture and participates in inflammatory and hemostatic responses, potentially stabilizing or propagating the thrombus.

Pathway placement
Cascade stepFibrous-cap degradation & rupture
Confidencemedium
RationaleFibrinogen-like protein elevated after plaque rupture; inflammation and thrombosis.
Also acts inVascular inflammation, Coagulation / thrombus
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000104760

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(3)