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Growth arrest-specific 6 (Gas6)
Pathway / Platelet adhesion & activation

Growth arrest-specific 6 (Gas6)

GAS6protein

Growth arrest-specific 6 is a vitamin-K-dependent ligand of the TAM receptor family (AXL, MERTK, TYRO3). Released on platelet activation, it signals through platelet TAM receptors to potentiate degranulation, integrin αIIbβ3 activation and clot stabilization, linking platelet activation to thrombus growth in atherothrombotic MI. The Gas6/AXL axis is also upregulated in STEMI and implicated in vascular inflammation.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleGas6, via platelet TAM receptors (AXL/MERTK/TYRO3), amplifies platelet activation and stabilizes the growing thrombus; genetic/pharmacologic Gas6 loss protects against arterial and venous thrombosis without prolonging bleeding.
Also acts inCoagulation / thrombus, Endothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000183087

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
58
C — confounder / Type-II
63
A — assay feasibility
72
E — evidence strength
26
T1DI (composite)
9
Specificity differential (R−C)-5.4
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(6)