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Glycoprotein Ib
Pathway / Platelet adhesion & activation

Glycoprotein Ib

GP1BAprotein

GPIb mediates platelet tethering to exposed von Willebrand factor at the site of endothelial rupture or erosion, initiating platelet adhesion and activation.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
Rationalevon Willebrand factor receptor; platelet adhesion and shear-dependent activation anchor.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000185245

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
85
C — confounder / Type-II
56
A — assay feasibility
72
E — evidence strength
32
T1DI (composite)
15
Specificity differential (R−C)+29.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(18)