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Extracellular Signal-Regulated Kinase 1
Pathway / Platelet adhesion & activation

Extracellular Signal-Regulated Kinase 1

MAPK3protein

ERK1 participates in platelet activation signaling and integrates with p38 pathways to amplify platelet recruitment and aggregation.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleERK1/2 platelet signaling cascade; p38 cross-talk in platelet activation.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates6
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000102882

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
54
C — non-Type-I
73
A — assay feasibility
72
E — evidence strength
31
T1DI (composite)
9
Specificity differential (R−C)-18.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(2)