Mitochondrial tRNA leucine

MT-TL1rna

Mitochondrial tRNA methylation patterns in platelets reflect mitochondrial function during thrombotic activation.

Pathway placement

Cascade stepPlatelet adhesion & activation

Confidencemedium

RationalePlatelet mtDNA methylation status indicates mitochondrial integrity and platelet bioenergetic capacity.

Also acts inVascular inflammation

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000209082

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood (transcript)

Collection tube

PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)

Method / principle

RT-qPCR (TaqMan) or small-RNA sequencing

Reagent / substrate

Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)

Platform

qPCR instrument / NGS

Turnaround · availability

Research / send-out · Research (few LDTs)