Non-catalytic tyrosine-protein kinase adaptor NCK1
NCK1geneNCK1 couples receptor tyrosine kinases to actin remodeling; regulates platelet activation and adhesion signaling.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleSH2/SH3 adaptor; regulates cytoskeletal dynamics in platelet/endothelial signaling.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000158092
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
1
GWAS associations
Traits: myocardial infarction
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.