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P2Y12 Receptor
Pathway / Platelet adhesion & activation

P2Y12 Receptor

P2RY12gene

P2Y12 is the platelet ADP receptor central to platelet aggregation and thrombosis; therapeutic target for antiplatelet therapy.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleADP-activated platelet receptor; antithrombotic target; clopidogrel and prasugrel antagonist.
Druggability
DruggableYes
Known drugs / candidates15
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000169313

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
67
A — assay feasibility
52
E — evidence strength
52
T1DI (composite)
7
Specificity differential (R−C)-51.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathn/a
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedn/a
Coverage: 2/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 4 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.620
Open Targets association (myocardial_infarction)

Literature evidence(7)

Clinical trials(5)