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Pregnancy-associated Plasma Protein A
Pathway / Fibrous-cap degradation & rupture

Pregnancy-associated Plasma Protein A

PAPPAprotein

PAPP-A is a metalloproteinase elevated in atherosclerotic plaques that degrades extracellular matrix, promoting cap rupture and thrombosis.

Pathway placement
Cascade stepFibrous-cap degradation & rupture
Confidencehigh
RationalePAPP-A is a matrix metalloproteinase; marker of fibrous-cap degradation and plaque destabilization.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000182752

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
56
C — confounder / Type-II
68
A — assay feasibility
68
E — evidence strength
27
T1DI (composite)
8
Specificity differential (R−C)-11.2
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay
Reagent / substrate
Anti-PAPP-A antibody pair
Platform
Automated / ELISA
Turnaround · availability
Send-out · Clinical (obstetric)/research

Human genetic evidence

0.025
Open Targets association (STEMI)

Literature evidence(11)