D2-40 podoplanin
PDPNproteinD2-40/podoplanin marks lymphatic endothelial involvement in coronary thrombus architecture.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencelow
RationaleLymphatic endothelial cell marker; identifies lymphatic infiltrate in thrombus composition.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000162493
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I62
C — confounder / Type-II53
A — assay feasibility68
E — evidence strength25
T1DI (composite)9
Specificity differential (R−C)+8.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Functions and Regeneration of Mature Cardiac Lymphatic Vessels in Atherosclerosis, Myocardial Infarction, and Heart Failure.Lymphatic research and biology · 2018 · PMID 30339474 · doi
- Co-expression of vascular and lymphatic endothelial cell markers on early endothelial cells present in aspirated coronary thrombi from patients with ST-elevation myocardial infarction.Experimental and molecular pathology · 2015 · PMID 26657000 · doi