Phosphatidylinositol 3-kinase class IB catalytic subunit
PIK3CBgenePIK3CB promotes phosphatidylinositol-3-kinase signaling downstream of CD40L, enhancing platelet activation and thrombus formation.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleElevated in incident AMI; mediates CD40L-driven platelet activation and aggregation.
Druggability
DruggableYes
Known drugs / candidates29
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000051382
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I23
C — confounder / Type-II42
A — assay feasibility52
E — evidence strength16
T1DI (composite)4
Specificity differential (R−C)-18.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(2)
- A Mass Spectrometry-Based Proteome Study of Twin Pairs Discordant for Incident Acute Myocardial Infarction within Three Years after Blood Sampling Suggests Novel Biomarkers.International journal of molecular sciences · 2024 · PMID 38473885 · doi
- Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α.Arteriosclerosis, thrombosis, and vascular biology · 2015 · PMID 25908768 · doi