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Tissue plasminogen activator
Pathway / Coagulation & thrombus formation

Tissue plasminogen activator

PLATprotein

Tissue plasminogen activator is released during coronary thrombosis and serves as a marker of fibrinolytic activity and thrombus burden in acute MI.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleFibrinolytic enzyme activation marker; elevated in rupture and thrombotic states indicating coagulation and fibrin turnover.
Druggability
DruggableYes
Known drugs / candidates8
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000104368

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.604
Open Targets association (myocardial_infarction)

Literature evidence(38)