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Tissue plasminogen activator
Pathway / Coagulation & thrombus formation

Tissue plasminogen activator

PLATprotein

Tissue plasminogen activator is released during coronary thrombosis and serves as a marker of fibrinolytic activity and thrombus burden in acute MI.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleFibrinolytic enzyme activation marker; elevated in rupture and thrombotic states indicating coagulation and fibrin turnover.
Druggability
DruggableYes
Known drugs / candidates8
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000104368

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
50
A — assay feasibility
72
E — evidence strength
50
T1DI (composite)
12
Specificity differential (R−C)-35
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 2
4aPCI-related periproceduraln/a
4bstent thrombosismag 1
4cin-stent restenosisn/a
5CABG-relatedn/a
Coverage: 2/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 26 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.604
Open Targets association (myocardial_infarction)

Literature evidence(38)