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Cyclooxygenase-1
Pathway / Thromboxane amplification

Cyclooxygenase-1

PTGS1gene

COX-1 generates thromboxane-A2, which amplifies platelet recruitment and aggregation during coronary thrombosis.

Pathway placement
Cascade stepThromboxane amplification
Confidencehigh
RationaleCatalyzes thromboxane-A2 synthesis in platelets; aspirin-sensitive step.
Druggability
DruggableYes
Known drugs / candidates64
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000095303

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
60
A — assay feasibility
52
E — evidence strength
86
T1DI (composite)
12
Specificity differential (R−C)-45
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 12 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.598
Open Targets association (myocardial_infarction)

Literature evidence(6)