Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1
RAPH1geneRAPH1 mediates Ras-dependent adhesion signaling; promotes integrin clustering and platelet-endothelial interaction.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleGTPase effector in Ras/Rap signaling; regulates actin dynamics and cell adhesion.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000173166
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
1
GWAS associations
Traits: myocardial infarction
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.