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Plasminogen activator inhibitor-1
Pathway / Coagulation & thrombus formation

Plasminogen activator inhibitor-1

SERPINE1protein

PAI-1 inhibits fibrinolysis and promotes a prothrombotic state favoring coronary thrombus formation and persistence.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencemedium
RationaleFibrinolytic inhibitor; shifts coagulation-fibrinolysis balance toward thrombosis.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000106366

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
67
C — confounder / Type-II
42
A — assay feasibility
72
E — evidence strength
58
T1DI (composite)
26
Specificity differential (R−C)+25
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossmag 1
3hypovolemia / dehydrationmag 1
4tachyarrhythmian/a
5hypoxemia / respiratory failuren/a
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 1
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 6 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma (activity: acidified, collect chilled)
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
ELISA (antigen) or chromogenic (activity)
Reagent / substrate
Anti-PAI-1 antibody pair; or tPA + chromogenic plasmin substrate for residual activity
Platform
ELISA plate / coagulation analyzer
Turnaround · availability
Send-out/research · Specialized/research

Human genetic evidence

0.028
Open Targets association (STEMI)

Literature evidence(60)

Showing 40 of 60 linked references.