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Plasminogen activator inhibitor-1
Pathway / Coagulation & thrombus formation

Plasminogen activator inhibitor-1

SERPINE1protein

PAI-1 inhibits fibrinolysis and promotes a prothrombotic state favoring coronary thrombus formation and persistence.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencemedium
RationaleFibrinolytic inhibitor; shifts coagulation-fibrinolysis balance toward thrombosis.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000106366

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
52
A — assay feasibility
72
E — evidence strength
58
T1DI (composite)
24
Specificity differential (R−C)+14.8
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossmag 1
2hypovolemia / dehydrationmag 1
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencymag 2
2high-demand / peri-operative stressmag 1
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 1
4bstent thrombosismag 2
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 9/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 16 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma (activity: acidified, collect chilled)
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
ELISA (antigen) or chromogenic (activity)
Reagent / substrate
Anti-PAI-1 antibody pair; or tPA + chromogenic plasmin substrate for residual activity
Platform
ELISA plate / coagulation analyzer
Turnaround · availability
Send-out/research · Specialized/research

Human genetic evidence

0.028
Open Targets association (STEMI)

Literature evidence(60)

Showing 40 of 60 linked references.