Heat shock protein 47 (HSP47)
SERPINH1geneStabilizes and matures interstitial collagen in plaque fibrous cap, reducing rupture risk.
Pathway placement
Cascade stepFibrous-cap degradation & rupture
Confidencemedium
RationaleCollagen chaperone; fibrous-cap stability via collagen synthesis/maturation.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000149257
Type I vs non-Type I discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I38
C — non-Type-I51
A — assay feasibility52
E — evidence strength21
T1DI (composite)5
Specificity differential (R−C)-13.2
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.491
Open Targets association (myocardial_infarction)
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.