SLAM-Associated Protein
SH2D1AproteinSAP mediates platelet activation and platelet–leukocyte aggregation, amplifying thrombotic and inflammatory responses during acute coronary thrombosis.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationalePlatelet and lymphocyte adaptor protein; aggregation signaling and leukocyte cross-talk.
Also acts inVascular inflammation
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000183918
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Multiomics uncover the proinflammatory role ofdeletion after myocardial infarction in mice.American journal of physiology. Heart and circulatory physiology · 2023 · PMID 36800508 · doi
- Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.Blood · 2005 · PMID 16037392 · doi