2,3-dinor-thromboxane B2

metabolite

2,3-dinor-thromboxane B2 is a urinary metabolite reflecting systemic thromboxane-A2 production, a COX-1-dependent amplifier of platelet recruitment and aggregation in coronary thrombosis.

Pathway placement

Cascade stepThromboxane amplification

Confidencehigh

RationaleStable urinary metabolite of thromboxane-A2 generation.

Also acts inPlatelet activation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum, plasma or urine

Collection tube

Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container

Method / principle

LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available

Reagent / substrate

Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent

Platform

LC-MS/MS; some automated chemistry

Turnaround · availability

Send-out / research · Specialized / research

Literature evidence(1)

Biomarkers of in vivo platelet activation in coronary artery disease: a systematic review and meta-analysis: communication from the SSC of the ISTH.
Journal of thrombosis and haemostasis : JTH · 2025 · PMID 40685139 · doi