Amyloid-beta 1-40

peptide

Amyloid-beta 1-40 destabilizes atherosclerotic plaques by promoting matrix degradation, precipitating rupture and thrombosis.

Pathway placement

Cascade stepFibrous-cap degradation & rupture

Confidencemedium

RationalePlaque destabilization and mortality predictor in NSTE-ACS; promotes fibrous-cap degradation.

Also acts inPlatelet activation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)

Collection tube

K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)

Method / principle

Competitive/sandwich immunoassay or LC-MS/MS

Reagent / substrate

Anti-peptide antibody; or isotope-labeled internal standard (MS)

Platform

Immunoassay / LC-MS/MS

Turnaround · availability

Send-out / research · Research-grade