APC-PCI
proteinAPC-PCI (activated protein C-protein C inhibitor complex) reflects ongoing thrombin generation and coagulation amplification during coronary thrombosis.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleThrombin-protein C interaction marker; coagulation activation.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- Coagulation, fibrinolysis, and platelet activation in patients undergoing open and endovascular repair of abdominal aortic aneurysm.Journal of vascular surgery · 2011 · PMID 21684711 · doi