CoronaryAtlas logo
CoronaryAtlas
ATP
Pathway / Platelet adhesion & activation

ATP

metabolite

ATP depletion and extracellular accumulation drives platelet activation and signals myocardial ischemia during acute coronary occlusion.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleExtracellular ATP activates platelet purinoreceptors; marks ischemic myocardium.
Also acts inMyocardial injury, Systemic / off-pathway
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
62
A — assay feasibility
42
E — evidence strength
48
T1DI (composite)
5
Specificity differential (R−C)-47
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationmag 1
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 3
6hypertensive emergencymag 1
7high-demand / peri-operative stressmag 2
Coverage: 7/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 18 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research

Literature evidence(8)

Clinical trials(1)