CD144+ tissue-factor+ microparticles

complex

CD144+TF+ microparticles from activated endothelium carry tissue factor to trigger thrombin generation and fibrin deposition.

Pathway placement

Cascade stepCoagulation & thrombus formation

Confidencehigh

RationaleEndothelial microparticles bearing tissue factor; initiate extrinsic coagulation pathway.

Also acts inEndothelial activation/erosion

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Plasma (citrate for coagulation complexes)

Collection tube

Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich ELISA against neo-complex epitope

Reagent / substrate

Antibody pair recognizing the assembled complex

Platform

ELISA plate

Turnaround · availability

Research / send-out · Research/specialized