CD84
proteinCD84 mediates platelet-to-platelet adhesion and thrombus stabilization during coronary occlusion.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleSLAM adhesion molecule stabilizing platelet–platelet interactions in thrombus.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(2)
- Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis.PloS one · 2014 · PMID 25551754 · doi
- Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.Blood · 2005 · PMID 16037392 · doi