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Collagen
Pathway / Platelet adhesion & activation

Collagen

protein

Collagen exposure following fibrous-cap rupture or endothelial erosion triggers GPVI-mediated platelet adhesion and the initiation of thrombosis in Type 1 MI.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleExposed subendothelial collagen is primary platelet adhesion substrate; ECM target after fibrous-cap rupture.
Also acts inCap degradation / rupture
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
60
A — assay feasibility
68
E — evidence strength
15
T1DI (composite)
3
Specificity differential (R−C)-45
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationn/a
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 10 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(2)