Complement component 3a
peptideC3a activates complement-driven platelet recruitment and thromboinflammatory cascade in coronary thrombosis.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleComplement anaphylatoxin mediates platelet activation and thromboinflammatory amplification in thrombus.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade
Literature evidence(2)
- Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19.Frontiers in immunology · 2021 · PMID 34491250 · doi
- Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction.Thrombosis and haemostasis · 2009 · PMID 19718478 · doi