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Complement component 5a
Pathway / Platelet adhesion & activation

Complement component 5a

peptide

C5a recruits neutrophils and activates platelets, amplifying thromboinflammatory response in acute MI.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePotent complement anaphylatoxin recruiting neutrophils and activating platelets in thrombosis.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — non-Type-I
46
A — assay feasibility
66
E — evidence strength
16
T1DI (composite)
4
Specificity differential (R−C)-22.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Literature evidence(3)