Complement component 5a
peptideC5a recruits neutrophils and activates platelets, amplifying thromboinflammatory response in acute MI.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePotent complement anaphylatoxin recruiting neutrophils and activating platelets in thrombosis.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I23
C — confounder / Type-II36
A — assay feasibility66
E — evidence strength15
T1DI (composite)4
Specificity differential (R−C)-12.7
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade
Literature evidence(3)
- Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19.Frontiers in immunology · 2021 · PMID 34491250 · doi
- Serum extracellular vesicle protein levels are associated with acute coronary syndrome.European heart journal. Acute cardiovascular care · 2013 · PMID 24062934 · doi
- Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction.Thrombosis and haemostasis · 2009 · PMID 19718478 · doi