Endogenous thrombin potential
otherElevated endogenous thrombin potential indicates heightened coagulation capacity promoting thrombus formation.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleIntegrated measure of coagulation cascade capacity; reflects thrombin generation potential.
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I89
C — confounder / Type-II61
A — assay feasibility45
E — evidence strength33
T1DI (composite)10
Specificity differential (R−C)+28.4
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST)
Method / principle
Method depends on analyte chemistry
Reagent / substrate
Analyte-specific
Platform
Variable
Turnaround · availability
Research · Research
Literature evidence(3)
- Combined complement and coagulation activation in ST-elevation myocardial infarction: associations with myocardial injury and dysfunction.Frontiers in immunology · 2025 · PMID 41262246 · doi
- The utility of coagulation activity for prediction of risk of mortality and cardiovascular events in guideline-treated myocardial infarction patients.Upsala journal of medical sciences · 2018 · PMID 29299952 · doi
- Increased plasma thrombin potential is associated with stable coronary artery disease: An angiographically-controlled study.Thrombosis research · 2017 · PMID 28477533 · doi