Glycoprotein Ib alpha
proteinGPIbα is the vWF-binding platelet receptor that initiates platelet tethering to exposed subendothelial collagen and injured endothelium, triggering downstream activation.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalevWF-binding platelet receptor; initiates tethering to injured surface.
Also acts inEndothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- Bivalirudin reduces platelet and monocyte activation after elective percutaneous coronary intervention.Thrombosis and haemostasis · 2009 · PMID 19190819