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GPV
Pathway / Platelet adhesion & activation

GPV

protein

GPV is a thrombin-activated platelet membrane protein released during platelet activation, indicating both thrombin generation and platelet responsiveness at the thrombotic site.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePlatelet membrane protein; thrombin-sensitive; released upon activation.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
47
C — confounder / Type-II
43
A — assay feasibility
68
E — evidence strength
20
T1DI (composite)
7
Specificity differential (R−C)+4.6
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(4)