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Hemoglobin
Pathway / Platelet adhesion & activation

Hemoglobin

protein

Released hemoglobin amplifies oxidative stress and promotes platelet activation and thrombosis in acute coronary occlusion.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleHeme-hemoglobin oxidative stress preceding STEMI; triggers platelet/thrombotic response.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
61
A — assay feasibility
84
E — evidence strength
67
T1DI (composite)
30
Specificity differential (R−C)+5.6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduralmag 2
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 6/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 19 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Whole blood (EDTA)
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
Automated spectrophotometry (cyanide-free SLS-Hb) on hematology analyzer
Reagent / substrate
Sodium lauryl sulfate (SLS) lysis reagent
Platform
Hematology analyzer (CBC); co-oximetry on blood gas
Turnaround · availability
STAT · Universal

Literature evidence(2)

Clinical trials(2)