L-tryptophan
metaboliteL-tryptophan dysregulation reflects platelet activation and thrombotic stress in acute coronary syndrome.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationalePlatelet activation biomarker; tryptophan metabolism dysregulation in ACS.
Also acts inThromboxane / COX-1
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I41
C — confounder / Type-II61
A — assay feasibility42
E — evidence strength23
T1DI (composite)4
Specificity differential (R−C)-20.1
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(2)
- Gut CommensalPromote Atherothrombosis via Regulating L-Tryptophan Metabolism.Reviews in cardiovascular medicine · 2024 · PMID 39618850 · doi
- Urinary metabonomic study of patients with acute coronary syndrome using UPLC-QTOF/MS.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2018 · PMID 30316136 · doi