miR-223
rnamiR-223 dysregulation in acute coronary events amplifies platelet activation and leukocyte recruitment, predicting post-MI mortality.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePlatelet-enriched miRNA; elevated in ACS; regulates platelet activation and monocyte functions.
Also acts inVascular inflammation, Coagulation / thrombus
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I54
C — confounder / Type-II70
A — assay feasibility50
E — evidence strength27
T1DI (composite)6
Specificity differential (R−C)-16.1
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(3)
- MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction.Biomolecules · 2022 · PMID 36139082 · doi
- A MicroRNA Signature in Acute Coronary Syndrome Patients and Modulation by Colchicine.Journal of cardiovascular pharmacology and therapeutics · 2020 · PMID 32356454 · doi
- Platelet microRNA for predicting acute myocardial infarction.Journal of thrombosis and thrombolysis · 2017 · PMID 29030746 · doi
Omics datasets(1)
- GSE283390GEOPlasma small extracellular vesicles of ischemic cardiomyopathy aggravate ventricular remodeling post-myocardial infarction through miR-223-3p-mediated dysfuncti