miR-361-5p
rnamiR-361-5p dysregulation in acute MI associates with altered coagulation cascade activation and adverse major events.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencemedium
RationaleACS-specific miRNA; dysregulated in acute MI; predicts MACE; likely regulates coagulation/thrombotic responses.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(2)
- Dysregulation of serum miR-361-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients.BMC cardiovascular disorders · 2021 · PMID 33546604 · doi
- Atherosclerosis-related circulating miRNAs as novel and sensitive predictors for acute myocardial infarction.PloS one · 2014 · PMID 25184815 · doi